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It is synthesised naturally from the amino acids lysine and methionine, primarily in the liver and kidneys, though it can also be obtained through dietary sources such as red meat and dairy products

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Because it is essentially water without sufficient solute, direct intravenous administration can cause red blood cell lysis (hemolysis) due to its hypotonic nature

Studies have shown that BTZ can sensitize peripheral sensory nerve fibers, resulting in overactivity of WDR neurons and subsequent abnormal pain or nociceptive hypersensitivity (Stockstill et al., 2018